Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia

Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP channel activity

Z Lacza

2002

Scholarcy highlights

  • Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP channel activity
  • Recent studies show the presence of a potentionally new isoform of the nitric oxide synthase enzyme in mitochondria, doubts have emerged regarding the physiological relevance of mitochondrial NOS
  • Nitric oxide synthase activity was measured in isolated brain and liver mitochondria using the arginine to citrulline conversion assay
  • In animals previously subjected to hypoxia, mitochondrial NOS activity was significantly higher than in the normoxic controls
  • We conclude that mtNOS is a constitutively active eNOS-like isoform and is involved in altered mitochondrial regulation during hypoxia

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