NADPH oxidase: a universal oxygen sensor?

Richard Jones is a Postdoctoral Research Fellow in Respiratory Medicine at the University of Hull, where he heads the pulmonary circulation research group

Richard D Jones; John T Hancock; Alyn H Morice

2002

Scholarcy highlights

  • Richard Jones is a Postdoctoral Research Fellow in Respiratory Medicine at the University of Hull, where he heads the pulmonary circulation research group
  • NADPH oxidase is classically regarded as a key enzyme of neutrophils, where it is involved in the pathogenic production of reactive oxygen species
  • NADPH oxidase-like enzymes have recently been identified in non-neutrophil cells, supporting a separate role for NADPH-oxidase derived oxygen species in oxygen sensitive processes
  • This article reviews the current literature surrounding the potential role of NADPH oxidase in the oxygen sensing processes which underlie hypoxic pulmonary vasoconstriction, systemic vascular smooth muscle proliferation, carotid and airways chemoreceptor activation, erythropoietin gene expression, and oxytropic responses of plant cells
  • A Lecturer in Medicine at the University of Cambridge, and Senior Lecturer Reader in Medicine at The University of Sheffield, his main research interest is the role of hypoxia in control of pulmonary arterial tone

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