Protein kinase C signaling and oxidative stress

Oxidative stress is involved in the pathogenesis of various degenerative diseases including cancer

Rayudu Gopalakrishna; Susan Jaken

2002

Scholarcy highlights

  • Oxidative stress is involved in the pathogenesis of various degenerative diseases including cancer
  • PKC is a logical candidate for redox modification by oxidants and antioxidants that may in part determine their cancer-promoting and anticancer activities, respectively
  • The two domains of PKC respond differently to two different type of agents: oxidants selectively react with the regulatory domain, stimulate cellular PKC, and signal for tumor promotion and cell growth
  • Antioxidant chemopreventive agents react with the catalytic domain, inhibit cellular PKC activity, and interfere with the action of tumor promoters
  • Dr Rayudu Gopalakrishna is an Associate Professor in the Department of Cell and Neurobiology, University of Southern California. He obtained his Ph.D. in Biochemistry in 1979. He carried out his postdoctoral studies at the National Cancer Institute, Bethesda, MD, on Ca2+- dependent cellular regulation focusing on calmodulin and protein kinase C
  • His current research interests includes understanding the oxidative regulation of protein kinase C by oxidant tumor promoters and cancer-preventive agents
  • Her research involves the identification of novel cytoskeletal protein kinase C binding proteins and substrates and their roles in mammary carcinogenesis

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