Altered Pharmacodynamics of Cardiovascular Drugs and Their Relation to Altered Pharmacokinetics in Elderly Patients

Pathophysiologic changes of aging and hypertension alter pharmacodynamic responses to cardiovascular drugs

Darrell R. Abernethy

2018

Scholarcy highlights

  • Pathophysiologic changes of aging and hypertension alter pharmacodynamic responses to cardiovascular drugs
  • For beta-adrenergic antagonists and calcium antagonists these changes do not develop in parallel with the pharmacokinetic changes of aging for these drugs
  • With a linked understanding of altered pharmacodynamics and pharmacokinetics can the elderly patient be optimally treated with these drugs

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