Thyroid hormone deiodination in tissues of American plaice, Hippoglossoides platessoides: characterization and short-term responses to polychlorinated biphenyls (PCBs) 77 and 126

We have described the tissue distribution and properties of thyroid hormone deiodination activities of the marine American plaice, Hippoglossoides platessoides

Bruce A. Adams; Daniel G. Cyr; J.Geoffrey Eales

2002

Scholarcy highlights

  • We have described the tissue distribution and properties of thyroid hormone deiodination activities of the marine American plaice, Hippoglossoides platessoides
  • We studied the 1- or 4-week responses of the plaice liver and brain deiodination activities and the plasma thyroxine and 3,5,3′-triiodothyronine levels to an intraperitoneal injection of the polychlorinated biphenyl congeners 77 or 126
  • At 1 week post injection hepatic T4ORD activity was increased and plasma T3 levels lowered by PCB 77, while hepatic inner-ring deiodination activity was increased by PCB 126
  • PCBs given in vitro compared with T4 for binding sites on plasma proteins or altered hepatic deiodination activity, indicating no direct action on plasma proteins or deiodinases We conclude that plaice TH deiodination tissue distribution and characteristics resemble those of other teleosts
  • Deiodination activities are low at natural assay temperatures but at 1 week show some responses to PCBs 77 and 126
  • Deiodination activities are low at natural assay temperatures but at 1 week show some responses to polychlorinated biphenyl 77 and 126

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