Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone

Our results indicate that direct correlations between quantitative computed tomography density and mechanical properties reduce errors in mechanical property predictions

David L. Kopperdahl

2002

Scholarcy highlights

  • Finite element models based on three-dimensional reconstruction of quantitative computed tomography scans have been used to investigate the strength of the proximal femur, to quantify damage and its repair in vertebrae, to study boneimplant systems, and to differentiate between vertebrae with and without osteoporosis
  • Since the accuracy of the output of these finite element models depends in part upon the material properties assigned to the trabecular bone, improved accuracy of the relationships between apparent bone mineral density measured by QCT density and the mechanical properties of trabecular bone should help optimize the potential of this technology, both in the research and clinical
  • A number of studies have sought to improve predictions of vertebral body strength by employing QCT 117,191, there currently exist no QCT density-mechanical property regressions in the literature for trabecular bone specimens that are free of the substantial end-artifact errors that arise from the traditional method of testing bone between platens
  • The objective of this study was to present correlations between QCT density and the modulus, yield stress, and yield strain of human vertebral trabecular bone that should improve the fidelity of QCT-based finite element models of the human spine
  • Input of material properties from the density information in QCT scans is a critical component contributing to the fidelity of QCT-based finite element models
  • Regardless of which strategy is used to describe the failure properties, use of the data presented here should improve the fidelity of QCT-based finite element models of the human spine and should provide realistic estimates of the errors associated with material property estimation from QCT scans
  • Regardless of which strategy is used to describe the failure properties, use of the data presented here should improve the fidelity of quantitative computed tomography-based finite element models of the human spine and should provide realistic estimates of the errors associated with material property estimation from QCT scans

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