Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers

New colloidal systems for ocular application were developed and their capacity for increasing the corneal penetration of drugs investigated

Pilar Calvo

2002

Scholarcy highlights

  • New colloidal systems for ocular application were developed and their capacity for increasing the corneal penetration of drugs investigated
  • Chitosan-coated and poly-l-lysine-coated poly-ϵ-caprolactone nanocapsules, were designed based on a strategy that combines the features of PECL nanocapsules as ocular carriers with the advantages of a cationic mucoadhesive coating
  • The cationic polyaminoacid PLL was directly adsorbed onto preformed PECL nanocapsules whereas the cationic polysaccharide CS was included in the nanocapsules formation medium
  • The ability of PLL-coated and CS-coated nanocapsules of enhancing the ocular penetration of indomethacin was substantially different: the CS coating increased twice, whereas the PLL coating failed to increase the ocular bioavailability of indomethacin when compared to the uncoated particles
  • The CS-coated nanocapsules represent a useful approach for increasing the ocular bioavailability of drugs

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