On shelf stability of freeze-dried poly(methylidene malonate 2.1.2) nanoparticles

Freeze-dried poly(methylidene malonate 2.1.2) -made nanoparticles were evaluated for their 12-month stability under various storage conditions of temperature and illumination

D. Roy

2002

Scholarcy highlights

  • Freeze-dried poly(methylidene malonate 2.1.2)-made nanoparticles were evaluated for their 12-month stability under various storage conditions of temperature and illumination
  • Nanoparticles maintained at 40°C underwent significant alterations revealed by the suspension pH decrease, the progressive modification of the HPLC chromatogram and the decreased cytotoxicity
  • Degradation of the polymer side chains and generation of carboxyl moieties could account for these observations
  • From the 1 year measurements here reported, lyophilized PMM 2.1.2 colloidal nanoparticles conserved at room temperature or below, either in darkness or in daylight, may be assumed to have a satisfactory shelf-life

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