Solid lipid nanoparticles as drug carriers. I. Incorporation and retention of the lipophilic prodrug 3′-azido-3′-deoxythymidine palmitate

Solid lipid nanoparticles were prepared with trilaurin as the SLN solid core and dipalmitoylphosphatidylcholine or a mixture of DPPC and dimyristoylphosphatidylglycerol to produce neutral and negatively charged SLNs

Hashem Heiati

2002

Scholarcy highlights

  • Solid lipid nanoparticles were prepared with trilaurin as the SLN solid core and dipalmitoylphosphatidylcholine or a mixture of DPPC and dimyristoylphosphatidylglycerol to produce neutral and negatively charged SLNs
  • The incorporation of AZT palmitate was greater in negatively charged SLNs than in neutral SLNs
  • The in vitro release of AZT-P from different SLNs formulation was studied at 37°C using a bulk-equilibrium reverse dialysis sac technique
  • Increased drug release was observed in SLNs formulated with PLs having a transition temperature below 37°C
  • The results obtained indicate that the highly packed TL core of the SLN is not compatible with lipophilic molecules such as AZT-P
  • The incorporation and subsequent retention of AZT-P appears to be dependent on the PL coating on the SLNs surface and is independent of the TL solid core
  • The incorporation and subsequent retention of AZT palmitate appears to be dependent on the PL coating on the Solid lipid nanoparticles surface and is independent of the TL solid core

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