Prestimulus modification of the startle reflex: relationship to personality and physiological markers of dopamine function

We examined the relationship of PPI in humans to putative markers of brain DA function: novelty seeking ), which is associated with specific DA receptor subtypes, and is reduced in Parkinson's Disease; blink rate, which is increased in primates by DA agonists, and is reduced in Parkinson's Disease

Neal R Swerdlow

2002

Scholarcy highlights

  • Prepulse inhibition, a measure of sensorimotor gating, is regulated by dopamine in rodents
  • We examined the relationship of PPI in humans to putative markers of brain DA function: novelty seeking), which is associated with specific DA receptor subtypes, and is reduced in Parkinson's Disease; blink rate, which is increased in primates by DA agonists, and is reduced in Parkinson's Disease
  • PPI, TPQ and blink rate were measured in 79 normal adult males
  • A significant negative correlation was observed between resting blink rate and mean PPI, but not between NS and PPI
  • PPI is inversely related to a physiological marker of resting DA tone, but not to a putatively DA-linked personality trait

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