Hormone synthesis and storage in the thyroid of human preterm and term newborns: Effect of thyroxine treatment

The present study investigates the iodine and Tg concentrations and the T4 and T3 content of Tg in thyroids of preterm and term newborns and older infants born at term

Marie France van den Hove; Christian Beckers; Hugo Devlieger; Francis de Zegher; Philippe De Nayer

2002

Scholarcy highlights

  • In the human fetus, the thyroid follicular cells are able to concentrate iodide and to synthesize thyroid hormones by the 11th week of gestation
  • Five very preterm and seven preterm newborns received a daily dose of 10 μg/kg L-T4 for at least 3 days
  • The L-T4 treatment of preterm newborns does not accelerate the maturational process of the thyroid gland
  • The thyroid weight, the intrathyroidal iodine and Tg concentrations, as well as the iodine, T3, T4 and sialic acid contents of Tg were measured in preterm and term newborns who died in the neonatal period and in older infants born at term
  • These observations show that during human ontogenesis, the thyroid weight and the sialic acid content of Tg increase with maturation while the concentrations of iodine and Tg do not increase within the thyroid of neonates before the 42nd week of postmenstrual age
  • Forty-six patients reached the primary end points of survival to transplantation, alive on the original device at 180 days and listed for transplantation, or explant for recovery
  • We examined the expression of endothelin 1 and endothelin receptor A at the protein and messenger RNA levels in 123 papillary thyroid carcinomas and 40 matched lymph nodes with metastatic papillary thyroid carcinomas
  • STZ/N-treated rats increased fasting blood glucose compared to control rats eight days and 2 months post-STZ/N injections indicating stable induction of T2DM state

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