Familial comparison of bone mineral density at the proximal femur and lumbar spine

Familial resemblance of bone mineral density was studied in the lumbar spine and three regions of the proximal femur in biological mother-daughter, mother-son, 24 mother-grandmother pairs and 18 mother-grandmother-daughter triads

H.A. McKay

2008

Scholarcy highlights

  • Familial resemblance of bone mineral density was studied in the lumbar spine and three regions of the proximal femur in biological mother-daughter, mother-son, 24 mother-grandmother pairs and 18 mother-grandmother-daughter triads
  • Children were placed into three maturity categories based on an assessment of secondary sex characteristics and growth velocities
  • Two sets of standardized BMD Z-scores were derived for the children based on either their chronological age or their maturational status
  • These scores were compared with maternal Z-scores derived from age-specific norms
  • The absolute BMD values measured in the grandmothers and the three maturity groups of the children — expressed as a percentage of the BMD of the mothers — showed that at the neck and the trochanteric regions of the proximal femur the late-pubescent girls and boys had a significantly greater bone density than their mothers, whereas at the AP spine these groups averaged only 88% of their mothers BMD
  • The value of incorporating maturity-based versus chronological-based parameters for comparison with adult measures in studies that involve growing children at different stages of development was demonstrated

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