Influence of microemulsions on cutaneous drug delivery

In attempt to increase cutaneous drug delivery, microemulsion vehicles have been more and more frequently employed over recent years

Mads Kreilgaard

2002

Key concepts

Scholarcy highlights

  • In attempt to increase cutaneous drug delivery, microemulsion vehicles have been more and more frequently employed over recent years
  • Microemulsion formulations have been shown to be superior for both transdermal and dermal delivery of lipophilic compounds, and hydrophilic compounds appear to benefit from application in microemulsions compared to conventional vehicles, like hydrogels, emulsions and liposomes
  • The vehicles may act as penetration enhancers depending on the oil/surfactant constituents, which involves a risk of inducing local irritancy
  • A few studies have indicated that the internal structure of microemulsions should allow free diffusion of the drug to optimise cutaneous delivery from these vehicles

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