Cytokine induced modulation of MHC class I and class II molecules on human cervical epithelial cells

Our purpose was to determine the expression of the major histocompatibility complex class I and class II gene products as well as the costimulatory molecules B7-1 and B7-2 on cervical epithelial cells, and to determine to what extent inflammatory cytokines regulate their expression

Git Ljunggren

2002

Scholarcy highlights

  • Our purpose was to determine the expression of the major histocompatibility complex class I and class II gene products as well as the costimulatory molecules B7-1 and B7-2 on cervical epithelial cells, and to determine to what extent inflammatory cytokines regulate their expression
  • MHC class I but not class II molecules were constitutively expressed on tissue sections and primary epithelial cell cultures derived from endo- and ectocervix
  • The induction of class II expression was more pronounced on ectocervical cells than on endocervical cells
  • Expression of the costimulatory molecules B7-1 and B7-2 were not detected in tissue sections or on resting or cytokine-treated cervical epithelial cells in vitro
  • The present results support the concept that endo- and ectocervical epithelial cells, like their counterparts at other mucosal sites, constitutively express MHC class I molecules and can express MHC class II upon cytokine stimulation, indicating that they are capable of presenting antigens to T-cells
  • The present results support the concept that endo- and ectocervical epithelial cells, like their counterparts at other mucosal sites, constitutively express major histocompatibility complex class I molecules and can express MHC class II upon cytokine stimulation, indicating that they are capable of presenting antigens to T-cells

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