Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex

We studied the effective spread of lidocaine to inactivate neural tissue in the frontal cortex of the rhesus monkey

Edward J Tehovnik

2002

Neuronal blockade with lidocaine has been used to study a variety of behaviours such as eye movements, drinking, and the avoidance of noxious stimuli
Normalized unit activity is plotted as a function of time after a lidocaine injection for different conditions
To achieve shutdown of the neurons in 6 of 6 cases, 7 vl of lidocaine were necessary
Anywhere from 1 to 30 vl of lidocaine were injected in these studies, volumes comparable to those used in the current study
The concentration of lidocaine used in these studies was somewhat higher at 4% rather than at 2% as used in the current study
By noting the timecourse and effective spread of lidocaine in cortical tissue, investigators will be better able the assess the significance of behavioural deficits, or lack of, arising from targeted injections of lidocaine into different cortical areas

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