Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties

We have evaluated these phenomena and discussed theories that reconcile complement activation and opsonization with prolonged circulation times

S.M. Moghimi

2003

Scholarcy highlights

  • This article critically examines and evaluates the likely mechanisms that contribute to prolonged circulation times of sterically protected nanoparticles and liposomes
  • It is generally assumed that the macrophage-resistant property of sterically protected particles is due to suppression in surface opsonization and protein adsorption
  • Recent evidence shows that sterically stabilized particles are prone to opsonization by the opsonic components of the complement system
  • We have evaluated these phenomena and discussed theories that reconcile complement activation and opsonization with prolonged circulation times
  • Stimulated or newly recruited macrophages can recognize and rapidly internalize sterically protected nanoparticles by opsonic-independent mechanisms

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