Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application

In this study we evaluated new colloidal systems for FLU ophthalmic delivery

R Pignatello

2002

Scholarcy highlights

  • The inflammatory response of the ocular tissues is a common side-effect associated to ophthalmic surgery
  • One formulation was tested in the rabbit compared to a commercial eye-drop product containing an equivalent amount of FLU sodium salt
  • ATS-nanostructured lipid carriers achieved up to 40% in vitro drug release in 1 h, while ex vivo permeation studies revealed that formulating ATS as NLCs enhanced permeation through pig nasal mucosa better than drug solution
  • The activity and reduction in parasitaemia by ATS-NLCs administered through the intranasal route was comparable to intramuscular administration, respectively
  • Intranasal administration of NLCs of ATS has great potentials to serve as a satisfactory alternative to parenteral administration for the treatment of severe and cerebral malaria in both adults and children in remote areas of sub-Saharan Africa
  • Ibuprofen loaded nanosuspensions made from inert polymer resin, Eudragit RS 100showed enhanced bioavailability in aqueous humor with no toxicity to ocular tissues.It has been demonstrated that quasi-emulsion solvent diffusion technique avoids the toxic chemicals used in solvent evaporation techniques like utilized in flurbiprofen loaded polymeric nanoparticle suspensions prepared from Eudragit RS 100 and RL 100 polymer resins.Lipid-based systems like solid lipid NPs, surface-modified SLNs and liposomes have demonstrated effective treatment of glaucoma, and help in reducing the multiple time administration frequency and improved patient satisfaction as compared to the conventional eyedrops
  • In situ gelling delivery systems for the ocular administration of drugs has been a major focus of research over the past two decades, improving the treatment of diseases of the anterior segment of the eye by simple, safe, and reproducible drug administration

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