Common genetic determinants of vitamin D insufficiency: a genome-wide association study

We considered SNPs at or near six pre-specified vitamin D pathway candidate genes: vitamin D receptor, 1-╬▒hydroxylase, 25-hydroxylase, 24-hydroxylase, vitamin D binding protein, and 27- and 25-hydroxlyase

Thomas J Wang


Scholarcy highlights

  • Vitamin D is crucial for maintaining musculoskeletal health
  • A growing number of other conditions have been linked to vitamin D insufficiency, causal associations have not yet been established in randomized trials
  • Given the strong association of genetic variants at GC with 25-hydroxyvitamin D concentrations, we examined whether these variants were associated with serum D binding protein, which was measured in 1,674 individuals in the Twins UK cohort
  • We showed that GC variants associated with lower 25-OH D concentrations were strongly related to lower levels of DBP
  • Gothenberg Osteoporosis and Obesity Determinants Study: Financial support was received from the Academy of Finland, University Hospital Oulu, Biocenter, University of Oulu, Finland, NHLBI grant 5R01HL087679-02 through the STAMPEED program, ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Medical Research Council, the Wellcome Trust, UK, and the Research Council UK fellowship
  • Aberdeen Prospective Osteoporosis Screening Study: Funding for APOSS cohort sample collection and analysis was supported in part by grants from the European Commission and the UK Food Standards Agency

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