Common genetic determinants of vitamin D insufficiency: a genome-wide association study

We considered SNPs at or near six pre-specified vitamin D pathway candidate genes: vitamin D receptor, 1-╬▒hydroxylase, 25-hydroxylase, 24-hydroxylase, vitamin D binding protein, and 27- and 25-hydroxlyase

Thomas J Wang

2010

Scholarcy highlights

  • Vitamin D is crucial for maintaining musculoskeletal health
  • A growing number of other conditions have been linked to vitamin D insufficiency, causal associations have not yet been established in randomized trials
  • Given the strong association of genetic variants at GC with 25-hydroxyvitamin D concentrations, we examined whether these variants were associated with serum D binding protein, which was measured in 1,674 individuals in the Twins UK cohort
  • We showed that GC variants associated with lower 25-OH D concentrations were strongly related to lower levels of DBP
  • Gothenberg Osteoporosis and Obesity Determinants Study: Financial support was received from the Academy of Finland, University Hospital Oulu, Biocenter, University of Oulu, Finland, NHLBI grant 5R01HL087679-02 through the STAMPEED program, ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Medical Research Council, the Wellcome Trust, UK, and the Research Council UK fellowship
  • Aberdeen Prospective Osteoporosis Screening Study: Funding for APOSS cohort sample collection and analysis was supported in part by grants from the European Commission and the UK Food Standards Agency

Need more features? Save interactive summary cards to your Scholarcy Library.