Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the mammalian homolog of ced-3, interleukin-1β-converting enzyme

Lin Wang; Masayuki Miura; Louise Bergeron; Hong Zhu; Junying Yuan

2004

Scholarcy highlights

  • We report here the isolation and characterization of Ich-1, a gene related to the C. elegans cell death gene ced-3 and the mammalian homolog of ced-3, interleukin-1β-converting enzyme
  • One mRNA species encodes a protein product of 435 amino acids that is homologous to both the P20 and P10 subunits of ICE and the entire CED-3 protein
  • Overexpression of the Ich-1s suppresses Rat-1 cell death induced by serum deprivation
  • These observations suggest that Ich-1 plays an important role in both positive and negative regulation of programmed cell death in vertebrate animals

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