Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

Our results show that Apaf1 is a central element in the mitochondrial pathways of programmed cell death induced in response to a wide range of apoptotic stimuli, but that Fas antibody -mediated PCD in thymocytes and activated T cells is independent of Apaf1

Hiroki Yoshida; Young-Yun Kong; Ritsuko Yoshida; Andrew J Elia; Anne Hakem; Razqallah Hakem; Josef M Penninger; Tak W Mak

2004

Scholarcy highlights

  • Apoptosis or programmed cell death is critical for the normal development of the body and occurs in many developing tissues in both invertebrates and vertebrates
  • Both Apaf1−/− thymocytes and activated T lymphocytes were sensitive to Fas antibody-induced killing, showing that Fas-mediated apoptosis in these cells is independent of Apaf
  • These data indicate that Apaf plays a central role in the common events of mitochondria-dependent apoptosis in most death pathways and that this role is critical for normal development
  • Our results show that Apaf is a central element in the mitochondrial pathways of PCD induced in response to a wide range of apoptotic stimuli, but that Fas-mediated PCD in thymocytes and activated T cells is independent of Apaf
  • Apoptosis determines the cytoarchitecture of the mature central nervous system to a significant degree (
  • Mutant embryos exhibited higher labeling index than wild-type littermates: 15.7% ± 2.9% vs. 10.1% ± 1.1% in the hindbrain at E12.5 and 40.2% ± 5.8% vs. 19.9% ± 4.8% in the forebrain at E13.5; mutant versus wild type
  • Fas-induced PCD in thymocytes and activated T cells is independent of Apaf
  • Fas antibody-induced programmed cell death in thymocytes and activated T cells is independent of Apaf

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