Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters

High molecular weight polyhydroxyalkanoates are synthesized and stored in the cell cytoplasm as water-insoluble inclusions by various microorganisms. This intriguing biological polyester initially attracted the attention of microbiologists and managed to keep many polymer scientists occupied over the second half of the last century

K Sudesh; H Abe; Y Doi

2002

Scholarcy highlights

  • High molecular weight polyhydroxyalkanoates are synthesized and stored in the cell cytoplasm as water-insoluble inclusions by various microorganisms. This intriguing biological polyester initially attracted the attention of microbiologists and managed to keep many polymer scientists occupied over the second half of the last century
  • Concerted multidisciplinary scientific approaches have been directed to the elucidation of various aspects of PHA
  • Of significant interest are the findings that PHA can consist of various hydroxyalkanoate monomers, and the cloning of its biosynthesis genes
  • It is possible that large-scale production of PHA by transgenic plants can be achieved in the near future
  • By controlling the monomer composition of PHA, polymer scientists have shown that the polymer's physical properties can be regulated to a great extent
  • This review attempts to bring together the biochemical and physicochemical aspects of PHA along with new perspectives on its potential therapeutic applications

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