Cell Death: The Significance of Apoptosis

The classification of cell death can be based on morphological or biochemical criteria or on the circumstances of its occurrence

A.H. Wyllie

2008

Scholarcy highlights

  • The classification of cell death can be based on morphological or biochemical criteria or on the circumstances of its occurrence
  • Irreversible structural alteration provides the only unequivocal evidence of death; biochemical indicators of cell death that are universally applicable have to be precisely defined and studies of cell function or of reproductive capacity do not necessarily differentiate between death and dormant states from which recovery may be possible
  • The other morphological pattern is characterized by condensation of the cell with maintenance of organelle integrity and the formation of surface protuberances that separate as membrane-bounded globules; in tissues, these are phagocytosed and digested by resident cells, there being no associated inflammation

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