The Zebrafish as a Model Organism to Study Development of the Immune System

Events in the development of the primitive and definitive blood forming system are still poorly understood. The specification of both B and T cells occurs during embryogenesis and, given the completion of this process before birth, are difficult to study in mammals by forward genetics

DAVID TRAVER; PHILIPPE HERBOMEL; E.ELIZABETH PATTON; RYAN D. MURPHEY; JEFFREY A. YODER; GARY W. LITMAN; ANDRÉ CATIC; CHRIS T. AMEMIYA; LEONARD I. ZON; NIKOLAUS S. TREDE

2004

Scholarcy highlights

  • Events in the development of the primitive and definitive blood forming system are still poorly understood. The specification of both B and T cells occurs during embryogenesis and, given the completion of this process before birth, are difficult to study in mammals by forward genetics
  • Rapid advances in a variety of fields have allowed the zebrafish to become a more versatile tool for immunology
  • ∗ indicates movies to be found at: http://www-alt.pasteur.fr/∼herbomel/

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