Synthèse de cétones α, α′-fonctionnalisées puis d'aldéhydes α-énols par ouverture des α-cyano α-hydroxyméthyl époxydes.

Two synthetic routes to α-enol aldehydes are described

K. Layachi

2002

Key concepts

Scholarcy highlights

  • Two synthetic routes to α-enol aldehydes are described
  • Monosubstituted α-enol aldehydes are obtained via Li2NiBr4/THF, ring opening of the trisubstituted α-cyano α-hydroxymethyl epoxides while disubstituted α-enol aldehydes are prepared through HX opening of the corresponding tetrasubstituted epoxide alcohols protected as acetate, followed by Ni(OAc) decyanation of the intermediate cyanhydrins and by NaOAc deprotection of the formed α,α′-functionalized ketones

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