A mathematical model for the investigation of the Th1 immune response to Chlamydia trachomatis

We investigate the Th1 cell-mediated immune response against Chlamydia-infected cells as the response changes over the chlamydial developmental cycle

D.P. Wilson; P. Timms; D.L.S. McElwain

2003

Scholarcy highlights

  • Chlamydia are bacterial pathogens of humans and animals causing the important human diseases trachoma, sexually transmitted chlamydial disease and pneumonia
  • Of the human chlamydial diseases, sexually transmitted disease caused by Chlamydia trachomatis is a major public health concern
  • We investigate the Th1 cell-mediated immune response against Chlamydia-infected cells as the response changes over the chlamydial developmental cycle
  • We suggest a form for the immune response over one developmental cycle by modelling the change in the number of intracellular chlamydial particles and assume peptides are presented in proportion to the number of replicating forms of chlamydial particles
  • We suggest that extending the length of the time of the lytic cycle will effectively decrease the required efficacy of the Th1 response to eliminate the pathogen
  • We produce plots of active disease progression, control and clearance for varying levels of Th1 effectiveness

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