Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat

Rasagiline is a selective irreversible MAO-B inhibitor as is deprenyl

M.C. Carrillo; C. Minami; K. Kitani; W. Maruyama; K. Ohashi; T. Yamamoto; M. Naoi; S. Kanai; M.B.H. Youdim


Scholarcy highlights

  • Rasagiline is a selective irreversible MAO-B inhibitor as isdeprenyl
  • The effect of the drug on antioxidant enzyme activities on dopaminergic tissue was examined in male F-344 rats
  • Three-and-one-half weeks later, animals were sacrificed and selected tissue samples removed from brain, kidney and heart
  • Several groups, including our own have reported an extension of survival of deprenyl-treated animals of different species
  • The mechanism(s) of the life extension by deprenyl remains unresolved, it would be interesting to investigate the effect of rasagiline on the survival of animals, since deprenyl was shown to increase antioxidant enzyme activities in brain dopaminergic regions

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