ORAL TRAZODONE IS NOT EFFECTIVE THERAPY FOR ERECTILE DYSFUNCTION: A DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL

The unusual side effect of priapism associated with the antidepressant trazodone has led researchers to evaluate its use for the treatment of erectile dysfunction

RAYMOND A. COSTABILE; MARIANNE SPEVAK

2006

Scholarcy highlights

  • The unusual side effect of priapism associated with the antidepressant trazodone has led researchers to evaluate its use for the treatment of erectile dysfunction
  • After a 3-month treatment interval patients were reevaluated with index scores and crossed over after a 3-week washout period
  • After the first 3-month treatment interval 19% of patients receiving trazodone had improved erections compared to 24% receiving placebo
  • Of the trazodone group 35% had improvement in sex drive compared to 20% of the placebo group
  • Mean Index of Sexual Satisfaction scores changed after treatment from 31.7 to 27.5 for the trazodone group and from 28.5 to 30.8 for the placebo group
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