Apolipoprotein E ε4 allele frequency in demented and cognitively impaired patients with and without cerebrovascular disease

We examined the apolipoprotein E phenotypes in a sample of 452 subjects: 219 with Alzheimer's disease, 45 with vascular dementia, 62 with mixed dementia, 45 with mild cognitive impairment without cerebrovascular disease, 27 in which vascular disease was the most probable cause of cognitive decline and 54 normal controls

Latchezar Traykov; Anne-Sophie Rigaud; Sophie Baudic; Alain Smagghe; François Boller; Françoise Forette

2002

Scholarcy highlights

  • We examined the apolipoprotein E phenotypes in a sample of 452 subjects: 219 with Alzheimer's disease, 45 with vascular dementia, 62 with mixed dementia, 45 with mild cognitive impairment without cerebrovascular disease, 27 in which vascular disease was the most probable cause of cognitive decline and 54 normal controls
  • The results range from increased ε4 frequency, similar to that found for Alzheimer's disease, to no association at all
  • Our objective was to clarify the relationship between ApoE ε4 allele and cerebrovascular disease in demented and cognitively impaired patients
  • We examined the ApoE phenotypes in a sample of 452 subjects: 219 with AD, 45 with VaD, 62 with mixed dementia, 45 with mild cognitive impairment without CVD, 27 in which vascular disease was the most probable cause of cognitive decline and 54 normal controls
  • The study of the ε4 allele frequency showed significant differences between: AD group and the VaD, VMCI and NC groups; MCI group compared with VMCI and NC groups; and MD group versus the VaD and NC groups
  • In contrast to other studies, we did not detect a relationship between ApoE ε4 allele and clinically diagnosed VaD
  • These findings should contribute to the assessment of dementia risk profile in the elderly

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