Determination of drugs in surface water and wastewater samples by liquid chromatography–mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri

In the present work a combined analytical method involving toxicity and liquid chromatography–electrospray ionization-mass spectrometry was developed for the determination of pharmaceutical compounds in water samples

Marinel·la Farré; Imma Ferrer; Antoni Ginebreda; Mercè Figueras; Lourdes Olivella; Lluis Tirapu; Manel Vilanova; Damià Barceló

2002

Scholarcy highlights

  • In the present work a combined analytical method involving toxicity and liquid chromatography–electrospray ionization-mass spectrometry was developed for the determination of pharmaceutical compounds in water samples
  • Sample enrichment of water samples was achieved by solid-phase extraction procedure, using the Merck LiChrolut® EN cartridges followed by LC–ESI-MS
  • The developed method was applied to real samples from wastewater and surface-river waters of Catalonia
  • One batch of samples was analyzed in parallel by High Resolution Gas Chromatography coupled with Mass Spectrometry and the results have been compared with the LC–ESI-MS method developed in this work

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