Effects of asbestos fibers on cell division, cell survival, and formation of thioguanine-resistant mutants in Chinese hamster ovary cells

The ability of crocidolite fibers to induce point mutations and mitotic abnormalities in Chinese hamster ovary cells was examined in cell cultures

K. Kenne

2005

Scholarcy highlights

  • The ability of crocidolite fibers to induce point mutations and mitotic abnormalities in Chinese hamster ovary cells was examined in cell cultures
  • The purpose has been to study the possibilities for establishing in vitro test methods to quantify genetic damage induced by asbestos and other mineral fibers
  • Results obtained with the CHO/hypoxanthine guanine phosphoribosyl transferase system indicated that crocidolite fibers per se do not significantly increase the number of thioguanine-resistant mutants
  • Among surviving cells some underwent abnormal cell divisions which resulted in multi- and micronucleate cells
  • The frequency of multinucleate cells was dependent on the dose of exposure to asbestos fibers and could possibly be used as an index of the degree of mitotic disturbances induced by mineral fibers

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