Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy

We found that complex III enzymatic activity was lower in Idiopathic dilated cardiomyopathy and in ischemic dilated cardiomyopathy patients when compared with normal controls

D Jarreta

2002

Scholarcy highlights

  • Idiopathic dilated cardiomyopathy is a severe condition that results in heart enlargement and impairment of the ventricular contractile function
  • Because myocardium depends heavily on oxidative metabolism, mitochondrial dysfunction might have a primary role in such disorders
  • Cardiac involvement has been found in a great number of mitochondrial diseases, either in association with neuromuscular symptoms or, less frequently, as the main clinical feature
  • The main finding was a significant decrease in enzymatic activity of complex III measured either isolated or together with complex I, independently if expressed as mg of protein or corrected by citrate synthase activity
  • When we tried to compare the activity of complex III with the classical parameters to measure heart failure, correlations were in general poor, end-diastolic diameter being the nearest to statistical significance
  • This could reflect the poor correlations that generally exist between classical measures of cardiac function and heart performance in end-stage cardiac failure
  • We conclude that the decrease of respiratory chain complex III activity found in both Idiopathic dilated cardiomyopathy and ischemic dilated cardiomyopathy favours the hypothesis of a secondary phenomenon, and not a primary mitochondrial disease in the majority of IDC patients

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