Protein Adsorption on Surfaces with Grafted Polymers

In this article we present a systematic theoretical study of the behavior of proteins adsorbing to surfaces in the presence of grafted polymers

I. Szleifer


Scholarcy highlights

  • Understanding the adsorption of protein molecules to surfaces is of primary importance in the design of biocompatible surfaces
  • Most of the results presented correspond to the adsorbed protein being spherical at the surface; we will study the effects of different configurations when the protein is at the surface
  • We have presented a general theoretical approach to studying the adsorption of protein molecules on surfaces with grafted polymers
  • The basic idea of the theory is to look at a central molecule, polymer or protein, with its intramolecular and surface interactions taken "exactly" into account and the intermolecular interactions considered within a mean-field approximation
  • For each type of molecule in the system, grafted polymer and protein, one must look at all of the possible configurations of a single molecule; the probability of that chain conformation will be given by its intramolecular and surface Boltzmann factors and the Boltzmann factor resulting from the intermolecular repulsive and attractive interactions that are derived from the theory
  • The intermolecular interactions are given by an interaction "field" that depends on the distance from the surface due to the inhomogeneous arrangements of the molecules induced by the presence of a surface

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