Biotransformations of R-(+)-pulegone and menthofuran invitro: Chemical basis for toxicity

Transformation of menthofuran by microsomes in the presence of NADPH yielded a metabolite identified as 2-Z-(2′-keto-4′-methyl cyclohexylidene) propanal. Formation of this α, β - unsaturated aldehyde was further confirmed by trapping it as cinnoline derivative by adding semicarbazide to the assay medium

K.M. Madyastha; C. Paul Raj

2005

Key concepts

Scholarcy highlights

  • Transformation of menthofuran by microsomes in the presence of NADPH yielded a metabolite identified as 2-Z-(2′-keto-4′-methyl cyclohexylidene) propanal. Formation of this α, β - unsaturated aldehyde was further confirmed by trapping it as cinnoline derivative by adding semicarbazide to the assay medium
  • The toxicity mediated by pulegone is discussed in the light of these observations

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