Mitochondrial bioenergetics as affected by DDT

The organochloride insecticide DDT depresses the phosphorylation efficiency of mitochondria as inferred from the decrease of respiratory control ratio and P/O ratio, perturbations of transmembrane potential fluctuations associated with mitochondrial energization and phosphorylative cycle induced by ADP

António J.M. Moreno; Vítor M.C. Madeira

2009

Scholarcy highlights

  • The organochloride insecticide DDT depresses the phosphorylation efficiency of mitochondria as inferred from the decrease of respiratory control ratio and P/O ratio, perturbations of transmembrane potential fluctuations associated with mitochondrial energization and phosphorylative cycle induced by ADP
  • DDT depresses the ΔΨ developed by energized mitochondria and prevents complete repolarization, that is delayed and resumed at a lower rate
  • DDT preferentially interacts with phosphorylation process in relation to respiration
  • High concentrations of DDT induce destruction of the structural integrity of mitochondria

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