Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product

This study has demonstrated that photoirradiated folic acid induces DNA damage

Kazutaka Hirakawa; Hiroyuki Suzuki; Shinji Oikawa; Shosuke Kawanishi

2003

Scholarcy highlights

  • This study has demonstrated that photoirradiated folic acid induces DNA damage
  • Fluorescence spectrum and HPLC analysis have demonstrated that photoirradiated folic acid generates PCA depending on the irradiation dose
  • Akhtar et al reported that PCA and p-aminobenzoyl-gulutamic acid are the photoproducts of UVA-irradiated folic acid
  • We have proposed the mechanism of PCA generation from photoexcited folic acid through an intramolecular electron transfer, following hydrolysis
  • Folic acid is a key factor in the physiological processes of cell metabolism; as it is involved in DNA synthesis and repair, it can be used in the treatment of aged and photo-damaged skin
  • This study describes the seroprevalence rates of Bluetongue virus in sheep flocks in southeast of Iran for the first time

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