We showed that -catenin gene mutations and -catenin overexpression in craniopharyngiomas were frequently and exclusively present in the adamantinomatous variant
2011
Key concepts
Scholarcy highlights
- Craniopharyngioma is a rare neoplasm occurring in the sellar region, comprising 3% of all intracranial tumors
- Multiple chromosomal abnormalities have been reported in two cases, no specific genetic alterations have been described so far. -Catenin is a submembranous component of the adherence junction, and it acts as a transcriptional activator of the Wnt signaling pathway
- Sequencing analysis revealed -catenin gene mutations in all 10 adamantinomatous craniopharyngiomas, whereas none were present in the 6 papillary craniopharyngiomas analyzed
- Epithelial cell nests and mesenchymal cells were separately microdissected and subjected to polymerase chain reaction followed by direct sequencing
- None of the papillary-type tumors harbored mutations, and all of them showed an exclusively membranous staining pattern as usually seen in nonneoplastic epithelial cells. -Catenin gene mutations and overexpression of -catenin are considered to be characteristics of adamantinomatous craniopharyngiomas
- We showed that -catenin gene mutations and -catenin overexpression in craniopharyngiomas were frequently and exclusively present in the adamantinomatous variant
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