Extrapolating the Fragment-Based Approach to Inorganic Drug Discovery
We describe selected compounds that form intra- or inter-DNA–DNA, DNA–protein, and protein–protein crosslinks
The fragment-based approach has delivered new targeted drugs in medicinal organic chemistry but has not yet been systematically applied to metal-based drugs
Bimetallic compounds with the ability to form strong covalent interactions with biomolecules have been shown to possess unique biological profiles
We demonstrate that the fragment-based approach represents an ideal way to design these bioactive compounds
Long range 1, 4 and 1, 6-interstrand cross-links formed by a trinuclear platinum complex
Et al Gold NHC-based homo-and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents.J. Biol
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