Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung

This study examines the potential of biodegradable polymeric nanoparticles composed of poly(lactic-co-glycolic acid) and the novel PLGA derivative, diethylaminopropylamine polyvinyl alcohol-grafted-poly(lactic-co-glycolic acid), to provoke inflammatory responses in the murine lung after intratracheal instillation

L.A. Dailey

2006

Scholarcy highlights

  • Particulate nanocarriers have been praised for their advantageous drug delivery properties in the lung, such as avoidance of macrophage clearance mechanisms and long residence times
  • This study examines the potential of biodegradable polymeric nanoparticles composed of poly(lactic-co-glycolic acid) and the novel PLGA derivative, diethylaminopropylamine polyvinyl alcohol-grafted-poly(lactic-co-glycolic acid), to provoke inflammatory responses in the murine lung after intratracheal instillation
  • All nanoparticle suspensions were instilled at concentrations of 1 μg/μl and 2.5 μg/μl, representative of an estimated “therapeutic dose” and a concentrated “dose” of particles
  • While the 75 nm and 220 nm PS nanospheres exhibited 41 and 74% PMN within the total bronchial alveolar lavage fluid cell population after 24 h, respectively, PMN recruiting in lungs instilled with both types of biodegradable particles did not exceed values of the negative isotonic glucose control
  • Evidence suggests that biodegradable polymeric nanoparticles designed for pulmonary drug delivery may not induce the same inflammatory response as non-biodegradable polystyrene particles of comparable size
  • Current address: Pharmaceutical Sciences Research Division, School of Pharmacy, King's College of London, 150 Stamford St., London SE1 9NN, UK

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