Ratiometric fluorescence detection of hydroxyl radical using cyanine-based binary nanoGUMBOS

We have developed a sensitive and selective ratiometric fluorescence nanoprobe for detection of hydroxyl radical

Mingyan Cong; Noureen Siraj; Nimisha Bhattarai; Paulina E. Kolic; Kevin S. McCarter; Pratap K. Chhotaray; Isiah M. Warner

2017

Scholarcy highlights

  • Overproduction of reactive oxygen species results in oxidative stress, which is closely associated with pathogenesis of many diseases
  • Confocal fluorescence imaging shows that this novel cyanine-based binary nanoGUMBOS probe is suitable for ratiometric detection of hydroxyl radicals in living cells
  • We have developed a sensitive and selective ratiometric fluorescence nanoprobe for detection of hydroxyl radical
  • Detection of hydroxyl radical was successfully demonstrated by use of these binary nanoGUMBOS in vitro using hormone-independent human breast adenocarcinoma cells
  • Noureen Siraj is currently an Assistant Professor at the University of Arkansas at Little Rock. She worked as a research associate in the Warner Research Group at Louisiana State University
  • Dr McCarter earned the Ph.D. in Statistics from Kansas State University, his dissertation research being in the area of life testing and survival analysis
  • His research interests include fluorescence spectroscopy, separation science, chemistry in organized media, ionic liquids, nanomaterials, and materials chemistry

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