An arylboronate-based fluorescent probe for selective and sensitive detection of peroxynitrite and its applications for fluorescence imaging in living cells

Peroxynitrite is an extremely reactive oxygen species in biological systems, and can react with a wide variety of molecular targets including proteins, lipids, and nucleic acids, eventually resulting in mitochondria dysfunction and cell death

Jian Zhang; Yaping Li; Jingjing Zhao; Wei Guo

2016

Scholarcy highlights

  • Peroxynitrite is an extremely reactive oxygen species in biological systems, and can react with a wide variety of molecular targets including proteins, lipids, and nucleic acids, eventually resulting in mitochondria dysfunction and cell death
  • We designed and synthesized a new arylboronate-based fluorescent probe, which could detect ONOO− with a big fluorescence off-on ratio, fast response rate, high sensitivity, and excellent selectivity over a series of biologically relevant reactive oxygen species as well as anions, cations, and biothiols
  • His research interests focus mainly on fluorescent dyes and probes as well as their applications for biological imaging

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