Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia

Five compounds reported from this species for the first time

Leonidah K. Omosa

2014

Scholarcy highlights

  • Five compounds reported from this species for the first time
  • Antifungal principles more lipophilic than antibacterial ones
  • The surface exudates of the leaves of Dodonaea angustifolia from Ngong forest population demonstrated antimicrobial activity against Gram-negative, Gram-positive bacteria and the fungus Sacchromyces cerevisiae
  • Good antifungal activities were observed for 5,4′-dihydroxy-7-methoxyflavanone and hautriwaic acid lactone against S. cerevisiae with minimum inhibition concentration values less than 7.8 μg/well
  • For comprehensive structure activity relationship studies, hautriwaic acid lactone, hautriwaic acid, penduletin isolated from the surface exudates of D. angustifolia from Voi and 12 and 13 from Senecio roseiflorus isolated earlier were included in the bioassays
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