Degradation mechanism of losartan in aqueous solutions under the effect of gamma radiation

These results show that degradation process starts with cleavage of the starting molecule by hydroxyl radicals, which are generated by the radiolysis of water

Amira Zaouak; Ahlem Noomen; Haikel Jelassi

2021

Scholarcy highlights

  • Gamma radiation degradation of a Losartan was studied in aqueous solutions
  • Deriving from sartan class, losartan, one of the most consumed antihypertensive drug was irradiated at doses of 0.5–4 kGy in aqueous solutions
  • During the mineralization process some aromatic intermediates such as 4- phenol, 2-butyl-4-chloro-5-(hydroxymethyl) imidazole-1-ol, 2,4′-dihydroxybiphenyl, tetrazole, 1,2,4 benzentriol, 1,4-hydroxyquinone and quinone were identified by LC/MS. These results show that degradation process starts with cleavage of the starting molecule by hydroxyl radicals, which are generated by the radiolysis of water
  • Losartan kinetic study was performed indicating a pseudo first order degradation process

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