Fabrication of cell patches using biodegradable scaffolds with a hexagonal array of interconnected pores (SHAIPs)

We report a novel type of porous scaffolds made of poly(D,L-lactic-co-glycolic acid) for fabricating cell patches

Yu Shrike Zhang

2013

Scholarcy highlights

  • The field of regenerative medicine has achieved tremendous progress in recent years with a goal to restore functional tissues that are damaged by injuries or diseases
  • When the lattice is only comprised of a single layer of microspheres, the resulting scaffold becomes what we refer to as the SHAIP
  • It is important to note a few unique features of SHAIPs: i) The pore size is uniform, which is inherited from the monodispersity of the microspheres used as the template
  • The uniform pores and windows represent a unique feature of SHAIPs since they can facilitate the diffusion of nutrients and wastes, ensure the homogenous distribution of cells at the time of seeding, and promote the migration of cells during the culture . iii) There are two openings on the two sides of each pore, which are defined as the surface pores
  • We have successfully fabricated PLGA scaffolds consisted of a single layer of spherical pores with a hexagonal arrangement, the so-called “scaffolds with a hexagonal array of interconnected pores”
  • Myoblasts cultured in SHAIPs were capable of differentiating into elongated myotubes in vitro and induce extensive neovascularization when implanted in vivo
  • Biophysical analyses are needed to assess the functional recovery of muscles in vivo

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