Refeeding abolishes beneficial effects of severe calorie restriction from birth on adipose tissue and glucose homeostasis of adult rats

We found that in rats, a severe calorie restriction beginning at birth up to adult age promotes positive effects on cardiometabolic risk factors and heart

Dirceu de Sousa Melo; Carina Sousa Santos; Liliane Costa Pereira; Bruno Ferreira Mendes; Larissa Santos Jesus; Juliana Maria Navia Pelaez; Edenil Costa Aguilar; Débora Ribeiro Nascimento; Almir de Sousa Martins; Flávio de Catro Magalhães; Elizabethe Adriana Esteves; Luciano dos Santos Aggum Capettini; Marco Fabrício Dias Peixoto


Scholarcy highlights

  • The aim of this study was to investigate the effects of this new model of severe calorie restriction on adipose tissue and glucose homeostasis of rats and to evaluate the effects of refeeding
  • From birth to 90 d of age, rats were divided into an ad libitum group, which had free access to food, and a CR50 group, which had food limited to 50% of that consumed by the AL group
  • Findings from this study revealed that SCR beginning at birth and up to adult life promoted a large decrease in visceral adiposity; improvement in glucose/insulin tolerance; and upregulation of adipose proliferating cell nuclear antigen, sirtuin 1, peroxisome proliferator-activated receptor-γ, and adiponectin
  • The authors have no conflicts of interest to declare

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