Eco-friendly procedure for the synthesis of 4-(Phenylamino)pent-3-en-2-one using an heterogeneous catalyst – ZnCl2/Natural phosphate

The results showed that the condensation reaction was carried out efficiently during 2 h at 35 °C in ethanol

Laila Laasri; Meryem Hadidi

2021

Scholarcy highlights

  • A new environmentally friendly synthesis of 4-(Phenylamino)pent-3-en-2-one has been developed by condensing aniline with acetylacetone using ZnCl2/Natural Phosphate
  • The results showed that the condensation reaction was carried out efficiently during 2 h at 35 °C in ethanol
  • The catalyst could be reused during two cycles without a significant loss in its activity
  • To investigate the environmental performance of this synthesis, a set of green chemistry metrics has been determined such as atom economy, reaction mass efficiency, stoichiometric factor, and material recovery parameter
  • We considered the Green Star Metric including simultaneously all of the principles of green chemistry
  • It appeared from the results that the environmental performance has been significantly improved when recycling catalyst and solvent, the use of less hazardous reagents us well us a renewable raw material is highly recommended to further improve the safety and the greenness of the developed synthesis

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