Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease

Mitochondria are the specialized organelles for energy metabolism and participate in the production of O2 active species, cell cycle regulation, apoptosis and thermogenesis

M Carreras

2004

Scholarcy highlights

  • Mitochondria are the specialized organelles for energy metabolism and participate in the production of O2 active species, cell cycle regulation, apoptosis and thermogenesis
  • Regulation of mitochondrial energy functions was based on the ADP/ATP ratio, which dynamically stimulates the transition between resting and maximal O2 uptake
  • NO stimulates the mitochondrial production of O2 active species, primarily O2− and H2O2, and, depending on NO matrix concentration, of ONOO−, which is responsible for the nitrosylation and nitration of mitochondrial components
  • Alteration in mitochondrial complexes restricts energy output, further increases O2 active species and changes cell signaling for proliferation and apoptosis through redox effects on specific pathways
  • MtNOS is important in the modulation of O2 uptake and cell signaling, and in mitochondrial pathology, including the effects of aging, dystrophin deficiency, hypoxia, inflammation and cancer

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