Mitochondrial enzyme activities as biochemical markers of aging

The decrease of neurological performance in normal aging is directly related to brain oxidative stress and inversely related to lifespan

Ana Navarro

2004

Scholarcy highlights

  • Mitochondrial enzyme activities as biochemical markers of aging
  • The decrease of neurological performance in normal aging is directly related to brain oxidative stress and inversely related to lifespan
  • The decrease in enzyme activities was directly related to the content of oxidation products and to the loss of neurological function in aged mice, this latter was determined in the tighrope and the T-maze tests
  • The above mentioned conditions that increased mice lifespan were effective to decrease the level of oxidative stress markers, and to retard the decreases in mitochondrial enzyme activities and neurological function associated to aging
  • The activities of mitochondrial nitric oxide synthase, NADH dehydrogenase and cytochrome oxidase may be used as indicators of the effectiveness of antiaging treatments

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