Ferrocenylvinyl-flavones: Synthesis, structure, anticancer and antibacterial activity studies

Our experiments show antibacterial activity for the carboxylic acid derivative 7 against all tested Gram-positive bacterial strains while no activity was detected for the ferrocene-free 6-bromo-chromen-4-one-3-propionic acid

Konrad Kowalski

2013

Scholarcy highlights

  • Four new ferrocenyl-flavone complexes were obtained via palladium-catalyzed Heck cross-coupling reactions;-6-ferrocenylvinyl-chromen-4-one,-6-ferrocenylvinyl-2-methyl-chromen-4-one,-6-ferrocenylvinyl-2-phenyl-chromen-4-one and-6-ferrocenylvinyl-chromen-4-one-3-propionic acid
  • Cytotoxic activity is related to apoptosis induction
  • All compounds were characterized by 1H NMR, 13C NMR, IR spectroscopy, high resolution-MS, elemental analysis and cyclic voltammetry
  • Our experiments show antibacterial activity for the carboxylic acid derivative 7 against all tested Gram-positive bacterial strains while no activity was detected for the ferrocene-free 6-bromo-chromen-4-one-3-propionic acid
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