Neutral and cationic mononuclear copper(II) complexes with enrofloxacin: Structure and biological activity

The mononuclear copper complexes with the quinolone antibacterial drug enrofloxacin in the presence or not of a nitrogen donor heterocyclic ligand 1,10-phenanthroline and 2,2′-bipyridine have been prepared and characterized

Eleni K. Efthimiadou

2006

Scholarcy highlights

  • The mononuclear copper complexes with the quinolone antibacterial drug enrofloxacin in the presence or not of a nitrogen donor heterocyclic ligand 1,10-phenanthroline and 2,2′-bipyridine have been prepared and characterized
  • Interaction of copper(II) with deprotonated enrofloxacin leads to the formation of the neutral complex Cu(erx)2(H2O), 1, while the presence of phen or bipy leads to the formation of a neutral or a cationic mononuclear complex, respectively
  • The complexes have been studied with X-band electron paramagnetic resonance in aqueous solutions at liquid helium temperature
  • The study of the interaction of the complexes with calf-thymus DNA has been performed with diverse spectroscopic techniques and has showed that all complexes are bound to DNA by the intercalative mode
  • The antimicrobial efficiency of the complexes has been tested on three different microorganisms and the available evidence supports that the best inhibition is provided by Cu(erx)2(H2O) against Escherichia coli and Pseudomonas aeruginosa

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