Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin

We demonstrate the feasibility to use microneedle arrays manufactured from commercially available 30G hypodermal needles to enhance the transport of compounds up to a molecular weight of 72 kDa

F.J. Verbaan

2006

Scholarcy highlights

  • We demonstrate the feasibility to use microneedle arrays manufactured from commercially available 30G hypodermal needles to enhance the transport of compounds up to a molecular weight of 72 kDa
  • Piercing of human dermatomed skin with microneedle arrays was studied by Trypan Blue staining on the SC side of the skin and transepidermal water loss measurements
  • Passive transport studies were conducted with Cascade Blue, Dextran–Cascade Blue, and FITC coupled Dextran
  • Microneedle arrays with needle lengths of 900, 700 and 550 μm are able to pierce dermatomed human skin as evident from the appearance of blue spots on the dermal side of the skin after Trypan Blue treatment and elevated TEWL levels after piercing compared to non-treated human dermatomed skin
  • Transport studies performed with model compounds ranging from 538 Da to 72 kDa revealed that pretreatment with microneedle arrays enhanced the transport across dermatomed human skin
  • We conclude that assembled microneedle arrays can be used to deliver compounds through the skin up to a molecular weight of at least 72 kDa

Need more features? Save interactive summary cards to your Scholarcy Library.